Do mods like kvma, or can rotten life corrupt an existing save in GAMMA ?

I may be dumb for asking, but recently i saw a tutorial made to improve the game visuals. The tutorial included mods such as Toxic air, KVMA, terrain texture redone or IXR texture rework. The thing is that i already start a new playthrough, and was wondering if it was safe to install those kind of mods on top of my game. Considering addons like hd models aren't compatible unless you restart a character, i am worried.