Where to stay in Denver over Christmas

There's about 6-8 family members looking to go to Denver over Christmas for a few days and wondering the best place to stay. We'll definately be going to the Bronco-Bills football game, but also want to check out the state/national parks, and I want to do some shopping (anything else that we should put on the agenda?-most of us have never been there). A couple of us are retired-age, I have some mobility issues and can't do extensive walking. I'm funding most of the trip and would prefer an upscale area with shopping, so I'm thinking maybe Cherry Creek. But I also want to be as accomodative to everyone as possible. The majority of our clan are in their 20's, so I'm sure they'll want to stay close to the nightlife/fun. Any recommendations that would make everyone happy? Would Cherry Creek work? Any other recommendations for our trip?