Random crashing

Since release of ROTW, I've been dealing with a sizeable amount of game crashing. It could be 3 minutes in, could be 33 minutes in (if I'm really lucky). I've reinstalled the game, ran a repair, deleted my cache, set a framerate cap, turned my graphics down... Nothing seems to repair the issue.

Is anyone else dealing with sporadic crashing? If so, what did you do to fix it? D2R is the only game I have any issues with.