[Questions] - Mac Studio Ultra 256GB and LLM

I would like to find out what types of LLMs can be run on a Mac Studio Ultra with 256GB version without requiring constant tweaking or optimisation.

For example, would models such as Qwen 3.8 27B, Qwen 3.8 Flash, or DeepSeek V4 Flash be able to simply load and run out of the box?

Or do these models generally require ongoing configuration, parameter adjustments, or other optimisation to run properly and efficiently?