When I created this group, I kept seeing the same questions:

* What should I measure?
* Which interventions are other APOE4 carriers trying?
* What actually happened after they tried them?
* Why does one person respond while another does not?
* How do we separate useful signals from internet noise?

Today, we are taking a meaningful step toward answering those questions.

We have published:

# APOE4: The Beat the Odds Study, Release 001

It brings together real-world data from **476 APOE4 carriers**:

* **30,737 biomarker readings**
* **185 members with at least one blood test**
* **139 with two or more blood tests**
* **176 observations where an intervention and biomarker moved together in a healthier direction**
* **Six intervention-marker patterns that repeated across members**

The report shows:

* What members tried for their brain health
* What happened to their biomarkers afterward
* Individual before-and-after cases
* Complete recorded protocols
* Patterns that repeated across members
* Findings that did not improve
* The limits and weaknesses of the current data

One member’s LDL fell from **263 to 78 mg/dL in 70 days** while taking ezetimibe and psyllium.

We included that result because it matters.

We also make clear that it does not prove the same intervention will work for everyone.

This is observational evidence, not a randomized clinical trial. It can surface signals and generate better questions. It cannot establish causation.

# Why this matters

No individual APOE4 carrier can test every potentially useful intervention alone.

At one experiment every three months, working through everything worth testing would take decades.

A community can do something one person cannot.

Hundreds of carriers can track different interventions in parallel. When people record their baseline, exact start date, complete protocol, daily changes, and repeat measurements, we can begin comparing similar cases.

We can ask:

* Did the result repeat?
* Who did not respond?
* What was different between them?
* Which intervention is the most plausible contributor?
* What should the person measure next?

That does not remove every confounding factor.

But it moves us beyond isolated stories and toward structured, shared learning.

**Download Release 001 free:**

[https://apoe4.link/redresearch001](https://apoe4.link/redresearch001)

The study is free and will be delivered to your email.

# Reading the study is the first step

The report can show what happened to other APOE4 carriers.

Phoenix is designed to help you investigate what happens in your own body.

Members can establish a baseline, log intervention dates and protocols, track daily changes, complete repeat tests, and compare their results with similar carriers.

Only **139 of the 476 members** in Release 001 had two or more blood tests.

That second measurement is what turns a health record into a before-and-after case.

If you carry APOE4 and want to build your own response profile while helping us make Release 002 stronger:

[https://thephoenix.community/start](https://thephoenix.community/start)

Please share the report with one APOE4 carrier, clinician, or researcher who should see it.

And tell me in the comments:

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Disclosure: I founded Phoenix, which is a paid APOE4 community. The study is free. It is educational and observational, not medical advice.

What 476 APOE4 carriers tried for their brain health, and what changed