Benefit of oral estradiol with shots but also with calcium d glucarate

So can anyone who knows more explain the biochemical reason as to why i require oral E2 cycles to compliment shots but also benefit from calcium d glucarate ?

If oral e2 increases metabolites but i benefit from it but also taking cdg helps with those metabolites being cleared.
Is it actually possible to need oral e2 for the estrone sulphate and estrone boost but also having to aid the clearance process ? In my mind people who have slow comt oral E2 is a no no for them because it raises the metabolites much more than injections am i wrong ?