Bad experience with retatrutide — considering tirzepatide. How were the side effects for you?

I’m curious to hear from anyone who has tried both retatrutide and tirzepatide.
I was taking retatrutide and unfortunately had a pretty rough experience with the side effects. At one point I accidentally took more than the dose I was supposed to be on. I eventually got back to feeling better and started taking the regular dose again, but even after giving it some time, I continued having side effects that I just couldn’t tolerate. Eventually I stopped because I honestly just didn’t like how I felt on it.
I recently got tirzepatide and I’m considering starting at 2.5 mg. I know that’s the typical starting dose, but after my experience with retatrutide, I’m nervous about whether I’m going to have the same issues — or potentially worse ones.
For anyone who has taken both retatrutide and tirzepatide:
Did you have fewer side effects on tirzepatide?
If retatrutide gave you bad GI side effects, did tirzepatide do the same?
How did you feel on the 2.5 mg starting dose?
Was the adjustment period easier with tirzepatide?
Did anyone actually tolerate retatrutide poorly but do really well with tirzepatide?
I know everyone reacts differently, but I’d really love to hear people’s personal experiences before I decide whether to start the tirzepatide.

Posted Sep 6, 2026, 3:28 AM UTC

011
Loading comments…