Pregnancy after tfmr for trisomy 18

Hi, I'm 39. I have an 8 year old healthy daughter. I conceived again in April this year at the age of 38.

At 18 weeks we had to terminate the pregnancy because amniocentesis came back positive for trisomy 18.

It was the hardest thing we ever had to do and something which I feel has changed us forever as a couple.

We got our genetic testing done and everything seems okay with both our chromosomes. The genetic counselor inferred that this was probably a sporadic event and the chance of trisomy 18 happening again are very very low. He said that because all our reports are normal, the most likely culprit is advanced maternal age. And as age advances the cell division becomes abnormal and leads to aneuploidies.

Now coming to my main question, my husband is very keen on us trying to conceive again. He genuinely feels that it was a stroke of sheer bad luck and that the chances of it happening again are very low.

I on the other hand feel that even though our reports have come back okay, if cell division due to my age was the reason this happened, then there is a chance that again my cells will divide abnormally and result into some other abnormality if not trisomy 18.

Can someone please help me out here with personal experiences? I want to have a child so bad but I'm scarred from the experience. Thank you for reading this far❤️

Posted Sep 8, 2026, 11:31 AM UTC

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