Bupropion-wellbutrin 150/300

Hey everyone! Let me give you some context on my situation

I'm currently on 5mg of Vortioxetine and 100mg of Lamictal. After my son was born, I started experiencing strong anhedonia and some difficulty making decisions, feeling less sharp and responsive than usual. I talked to my doctor about it, and he added Bupropion to give things an extra push, starting at 150mg a day.

In the first month at that dose, I noticed a modest improvement: mood was a bit more stable and I had better control over everyday choices. I was expecting a more noticeable effect early on though, a kind of "honeymoon phase," which never really showed up. A week ago I moved up to 300mg, and the result has been the opposite of what I hoped for: I feel physically exhausted, my sleep is off (either too little or too much), the anhedonia is back in full force, and I have almost no motivation to do anything. I'm supposed to get back to the gym after the summer break, but I keep putting it off without being able to snap out of it.

If anyone's been through something similar, I'd love to hear how it went — ideally a story with a happy ending 🥲

Posted Sep 8, 2026, 4:53 PM UTC

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