Any performance difference between USB install and internal install?

So I’ve been playing with Umbrel 2.0 this weekend on a small N150 mini pc. It only had 1 drive, so I’ve been running it off USB. I know it’s not a powerful pc, so I wasn’t surprised it was a bit slow. I’m thinking about trying to move it to a bigger machine next, and curious if running off usb is actually viable, or if I really should install on a dedicated drive.