r/Retatrutide•
tkw97

Is it common to feel it this strongly after your first dose?

I did my first injection (0.5mg) about 25 hours ago. Never taken GLP medications before. My BMI is currently 28.9 (so not obese, but def heavier side of overweight)

Didn’t eat anything for 18 hours and felt fine, and around 1-2pm today I got hungry and ordered a salad at work. Normally I can eat the entire salad no problem (it’s only 500-600 calories), but after eating ~half of the salad I suddenly got REALLY nauseous. Like, ran to the bathroom because I might throw up nauseous.

Didn’t end up doing so, but the nausea and burping were persistent and didn’t die down until I took some pepto bysmol with electrolytes. I managed to at least get a protein shake in during the late afternoon.

After I got home I worked out (nothing super intense just 20 min of some Apple Fitness body exercise videos) and of course the lack of food/energy did not have me feeling great (nausea/fatigue). I tried to eat some leftover spaghetti to get carbs in, and I maybe got 5 bites in until I started feeling nauseous again and stopped eating.

Did anyone else feel the effects this intensely within a day of their first dose, at 0.5mg? My partner and my dad say the first 2 weeks is always rough but I thought starting with a very low dose would make it seamless 😭

Posted Sep 30, 2026, 3:40 AM UTC · locked

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