Did anyone intentionally titrate up to a higher dose for the additional non-weight related benefits?

2.5mg is working well but for me, like many of us, this med is more than weight loss - cardiovascular health, water weight, inflammation, glucose control etc. I want all the benefits!

I'm also a woman and deal with water retention 12-14 days at a time, and am only free of bloat for maybe a 6 days total a month if I'm lucky. Tirz has given me the ability to lock in despite water covering up my progress, because it eventually all evens out... but it does suck dealing with the bloat and swelling (which admittedly is better on tirz, but still an issue).

I've found a few comments that a higher dose overrides the hormonal aspect and shuts the water retention down for some of us. And 5mg seems to be the well studied dose for the other benefits.

Anyone have any thoughts or deal with a similar decision?

Posted Sep 30, 2026, 3:42 AM UTC

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