If we did get an MHA sequel I would really like it if the league of villains reformed with a new leader and the express goal of not just taking down hero society but specifically to destroy Deku in every way possible because each of its core members has a deep seeded reason to hate Izuku midoriya. The members I would include would be the following 

Muscular: Over the years he developed a trigger addiction in his obsession to try and defeat midoriya, be now requires normal hits of trigger for his quirk to function properly and he's slowly dying and wants to fight Deku to the death before he goes braindead.

Re-Destro: Publicly disgraced and his company seized and most of his supporters gone, he joins the league to honor the memory and dream of tomura. He's completely bald now as his stress hit an all time high.

Overhaul: Broken and obsessed with eradicating quirks as he blames the existence of quirks for the downfall of everything he holds dear and he joined the league moreso out of spite and he's kept on a tight leash by spinner because he knows he's a backstabbing weasel. Essentially think Starscream, his hate for Deku in particular is comparable to how Thawne hates Barry.

Geten: Still devoted to Re-Destro, he follows him as a member of the league and while he doesn't exactly hate Deku he DOES hate shoto because of his connection not to endeavor to his his mother Rei and her side of the family who essentially threw him out like trash.

Mustard: Having spend a majority of his teenage years in prison, immediately after being released he commits an act of terrorism with his quirk which had awakened and his the gas he emitted could be poisonous/toxic. He holds a grudge against all of class 1A and every time he encounters them he has to remind them who he is because none of them ever remember him because he's that pathetic of a villain.

Flect Turn: After spending years in prison he learned to control his quirk and the battle with deku actually pushed him into awakening his quirk and it operates very similar to Gojo's infinity but with the added benefit of deflecting anything that is send his way directly back at the point of origin. He still controls small pockets of his cult and he works in collaboration with Re-Destro and Overhaul, moreso overhaul as they both have plans to backstab the league.

Dr. Garaki: His longevity quirk reached a limit however being a master of planning ahead he managed to digitally upload his mind to a computer and that computer was connected to an android body that can move around and has weapons. He acts as the main source of equipment upgrades and also Nomu creation for the league as they managed to salvage of the few remaining Nomu labs he had hidden.

Gigantomachia: Having survived his encounter with AFO the beast is now aimlessly and in search of a new master powerful enough to command him.

Spinner: Leader of the new league of villains, spinner has spent the last 8 years in jail growing in strength and intelligence, writing a book to honor Tomura and being new villains into the league. He mastered the body bulk quirk and scale quirk to the point where he can grow the scales and form them into a sword. He hates deku the MOST out of anyone and will take any chance to make his life miserable or difficult.

Mr. Compress: He's fully embraced his phantom thief persona and steals from and exposes corrupt heroes having been inspired by what Dabi did to bring down endeavor.

MHA Sequel: The Legion of Shigaraki