Does Nintendont work with Gamecube ISOs downloaded off the internet, on Wii?

Piracy is illegal and immoral.

But if you own the game, downloading copies from the internet is fine. They work just fine. In most cases you'd only do that if your copy is scratched or currently inaccessible for some reason.

Nintendont is the best option. Please read the sticky.

Yes, it works with them. Recently downloaded and installed a bunch.

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