How to fly home with a desktop?

Hey guys,

I've been back and forth for so long on building my own pc vs buying an Alienware laptop (yes I am fully aware of the performance advantage and price advantage from building). I had myself convinced that I would build a desktop, but I started wondering how I would get it home for the summer from school since I have to fly (and have a ton of shit to bring already). I was thinking of going with a mini itx build to minimize size. Do you have any tips, or things that worked with you to get your setup from A to B in the air without harm?