The run was a solid mix of jokes about rumors everyone heard as a kid, the tv show, and the recent twitchplayspokemon craze that happened a few years ago. If you haven't seen any of these / aren't into the game you'll likely have no idea what they're talking about, but it's never too late to pick up the game :)

I was in High School when Pokemon came out.

 After all these years, although I understand the premise, I still have no idea what I'm looking at right now.

People are clapping and I have no idea why. This must be what my grandparents feel like all day every day.

Pokemon -- I was too old for this craze... I have no idea what I'm watching