A space marine goes against the diablo universe

To quote Eric Bischoff's theme: I'm back, and im better than ever.

First time, a regular joe with some firepower took on the diablo universe. He didn't do too well. Then Commander Shepard, along with Wrex, took it on. They did better, but still had problems. Well I really want to kill these prime evil pricks. so, Im going further into the future. Say... 38,000 years?

Random space marine, you choose the chapter, I don't really care. He is armed with a Combi-Plasma gun, a hand flamer, an assault cannon, a chainsword, and regular armor. He starts in Diablo 1, and when he is finished in that, he goes to diablo 2, then diablo 3. He gets random drops of ammunition for his weapons (if they even have ammo, never been sure). His job is to kill the prime evils.

Can he do it?