Source
r/researchchemicals•
Cxper

Diclazepam Pg solution attempt, will added ethanol mix evenly?

So I stupidly just assumed diclazepam would work in pg just as etizolam and clonazolam do. My mistake.

I now have a 5mg/ml mix that just barely won't completely dissolve. Upon actually researching, I keep hearing 4mg/ml might be the max solubility. It's in a 30ml vial so adding more pg isn't ideal, and reading how well ethanol works for diclazepam, I'd like to add a small amount of ethanol.

I'm thinking 1ml, which wouldn't alter the concentration significantly. My concern is this: does pg and ethanol combine evenly? I worry if the diclazepam goes into solution in the ethanol, and it forms a layer, I'll have obvious issues.

If anyone has experience with this, I'd love input. To answer apparent questions, the current mix has been sitting for 24 hrs. It has been set in a hot water bath several times and agitated a lot.

Thanks in advance for any input!

Posted Jan 19, 2017, 12:57 AM UTC

36
Jmths•

Got 10mg/ml diclazepam in PG here. Sometimes it takes up to 2 days before its fully disolved with some benzodiazepines. Simply shaking the vial every now and then (and several days patience) has always be sufficiënt in my case, no heathing required.

I don't think adding ethanol is gonna improve the situation, PG has better solubility.

Never tried it with ethanol tough so I can't be certain. PG and ethanol should combine evenly.

2
RC_For_Science•

Also want to report I got diclazepam at 10mg/ml in PG and it was indeed about 2 days before it fully dissolved doing sessions of heat bath and vigorous shaking each day

2
throwaway34441144•

it should mix completely

weather that will get the diclazepam in solution or not i don't know, can you get another 30 ml vial? then you can add enough pg/ethanol for it to dissolve with no problem

1
CxperOP•

Thanks for the replies guys, my diclazepam was very crystalline and this morning still had some bigger chunks floating around. I added 1ml of everclear and it seemed to be helping right away.

I had to leave for work though, so I'll see what we're looking at when I get home. I've always avoided ethanol simply due to its tendency to evaporate over time but in this case that shouldn't matter much.

1
drdrizzy13•

i did it one time with 50/50 pg/everclear(190 proof) and the alcohol def dissolves it much faster

1
iamwastedyouth•

I don't understand all the issues peple have making Diclaz solutions. It literally takes me 30 minutes to make a 5mg/ml solution completely clear and ready for research. I've read these threads so many times I'm considering making a video tutorial.

1
CxperOP•

I mean that's been my exact experience making dozens of pg solutions with etizolam and clonazolam. Thirty minutes of hot water bath and some shaking would yield perfect solutions.

As I said though, this diclaz is quite crystalline compared to what I would consider a powder that I've gotten as clonazolam and etizolam. Etiz went into 10mg/ml no problem.

My addition of 1ml of ethanol to the 30ml pg solution has now dissolved all but one chunker crystal that's still in the mix. Maybe different synths or more powdered diclaz goes into solution easier. Or maybe I have a different chem here.

If you have any helpful ideas, I'm sure the community would appreciate it.

1
iamwastedyouth•

I think you're probably right regarding different synths or possible impurities. I always use the same vendor for my Diclazepam and it's always finely powdered vs a crystalline quality

1