Are there any drugs that act like the opposite of heroin/meth and feel horrible in the short term but make you feel good in the long run?

I don't mean for treating a specific illness. I mean that the rough story that gets told about most recreational drugs is that they make you feel really good and your ability to feel pleasure adjusts to compensate. Is there anything that does this in reverse, by making your pleasure centers or whatever adjust in the opposite direction to feel good all the time when not on the drug?