is my resume a hindrance? (and other pleas for advice)

I'm a recent grad who has spent over two months looking unsuccessfully for a job. The best luck I've had was a single interview for a job that ultimately threw up too many red flags for my comfort. I've gotten preliminary options from The Creative Group staffing agents and contacts from job fairs who dug my portfolio, and ultimately got nowhere. I realize that two months can be a slim amount of time for a job search, but it's long enough to have gotten me anxious that I'm doing it all wrong. Or worse, that I AM all wrong and my "presentables" are turning off potential employers.

I'm referring mainly to my resume. While I feel it is well-designed (although please feel to rip it apart), I'm afraid that turn-offs are lurking within, in the vein of implying that I'm under-experienced, over-compensating, or maybe even under-committed. I'll go semi-chronologically:

1. My best education seems irrelevant. I've struggled with career options (and a little bit of until-recently-untreated depression). Even though I did grow up with some artistic talent, I decided in high school to pursue the "practical" route of an economics degree. And I did have a lot of interest in the subject (spurred on by a great high school teacher), but I realized too late in that the field was not for me. Instead of looking for work in the field I grasped around various small freelance gigs and wage jobs. So maybe it's just sitting on my resume like a one-ton hood ornament, looking impressive but signaling little more than that I'm wishy-washy with my life choices and quite a bit older than other fresh talent.

2. My freelance experience is old and fleeting; my recent work experience is irrelevant. The design work I did after getting my first degree was paid, but for acquaintances and mutual friends; workable for them but not quite portfolio-worthy. The jobs I worked in the interim were just ways to get by with flexible scheduling; I did some creative work at those jobs when possible, but not often.

3. Yes, that Art Institute. For-profit trade schools have spotty and suspect reputations for good reason. Now I might be guilty of under-researching a bit, but for the location and time frame it was actually a convenient option. And I will vouch for most of the instructors, who are working professionals and offered solid training and advice. Still, I'm afraid that maybe people are looking at this and going "ugh, this guy's not legit." Especially since it's an Associate's degree.

4. Given the above, are my awards meaningless? My work did impress the pants off the faculty, and I was considered among the top students. I even beat out bachelors students in my class for Best Portfolio (and they all did top-notch work, some I considered better than mine). But if employers don't think the school's any good, these accolades show a Big Fish in a Small Pond at best (and, at worst, fruit of a poisoned tree).

Of course, another possibility is that my portfolio isn't cutting it; you can take a look and offer honest critique. Then there's the issue that I suffer from a decent amount of social anxiety and can sometimes be awkward in person. I might even be on the spectrum; I can freeze up during interactions with the slightest pressure riding on it. My instructors liked me but I had a hard time making friends and connections. I'm terrified of landing an interview with an awesome and hip design agency and then turning them off personally (All the agencies who profess a casual atmosphere and no-bullshit tone should be attractive, but they just say to me "you're not cool enough to work here").

If you've made it through the slog of this post, a) thanks and b) what can I do? Besides beefing up my portfolio with personal projects, which I'm working on. Should I restructure, tighten up or throw out my resume? Should I be more aggressive with my search, calling up each and every employer I apply to, or maybe even ship my resume and portfolio to companies that aren't even hiring? How do I build up good connections or even get internships now that I'm out of school? Do I look like I'm full of shit?

Any advice would be appreciated.