Most depressing thing for James Bond

I would say that having your car take a drink would be up there as well.

I like it in Casino Royale; his second kill is shooting a guy... they're talking about how hard the first kill is, and I believe it goes: Bad Guy: "Don't worry, the second one is-" PIFF (silenced gunshot) Bond: "Yes, considerably." I loled.

well at least he went out with a bang.