Antidepressants aren't making any difference

The Risperidone I'm on seems to mitigate positive symptoms, which I'm thankful for, but what seems impossible to treat is my crippling depression. I've been on and off several different antidepressants for years and none of them make me feel any better.

My current doctor has me on Venlafaxine, and recently added Mirtazapine. This cocktail is known as Californian Rocket Fuel and is supposed to be effective against treatment resistant depression, but I'm still lying in bed thinking about killing myself. It's only been a few days so maybe it hasn't kicked in yet, but I can't see it improving my mood much. It seems likely I'll be chronically depressed for the rest of my life.

Stranger Things season 2 is out now, TV shows are just about the only thing I still get some enjoyment out of, but I just can't be bothered watching it. I've lost interest in everything. Everything is a chore. I don't want to do anything. I feel so empty.

Does anyone else here suffer from major depression?