Sudden problem with VLC opening/running

Lately I have been unable to open any files with VLC, video or otherwise. The VLC window pops up, sits for a moment, then times out to Not Responding. Sometimes I can get into Preferences, sometimes not. I run Windows 7 64 bit and outside of a recent windows update all of my hardware has remained the same, no recent changes. I've run Windows Defender and Malwarebytes and nothing pops up. Is it possible that Windows Update has caused some problem with VLC running?

I have tried resetting the preferences, deleting the VideoLAN folder, and doing fresh re-installs.