Math on the first buff vs the second iteration

First buff iteration:

Zed Q base: 220

Zed Q base second hit: 154

Zed Q scaling: 110%

Zed Q scaling second hit: 82%

Zed E scaling: 90%

Zed R1 damage multiplier: 125%

Zed R3 damage multiplier: 145%

WEQ combo

20 AD full WEQ combo total: 220 + 154 + 22 + 16 + 18 = 430

100 AD full WEQ combo total: 220 + 154 + 110 + 82 + 90 = 656

200 AD full WEQ combo total: 220 + 154 + 220 + 164 + 180 = 938

300 AD full WEQ combo total: 220 + 154 + 330 + 246 + 270 = 1220

R level 1 combos:

20 AD full REQ (single Q) combo total: (220 + 22 + 18)/100*125 = 325

100 AD full REQ (single Q) combo total: (220 + 110 + 90)/100*125 = 525

200 AD full REQ (single Q) combo total: (220 + 220 + 180)/100*125 = 775

300 AD full REQ (single Q) combo total: (220 + 330 + 270)/100*125 = 1025

400 AD full REQ (single Q) combo total: (220 + 440 + 360)/100*125 = 1275

20 AD full RWEQ (double Q) combo total: (220 + 154 + 22 + 16 + 18)/100*125 = 537

100 AD full RWEQ (double Q) combo total: (220 + 154 + 110 + 82 + 90)/100*125 = 820

200 AD full RWEQ (double Q) combo total: (220 + 154 + 220 + 164 + 180)/100*125 = 1172

300 AD full RWEQ (double Q) combo total: (220 + 154 + 330 + 246 + 270)/100*125 = 1525

400 AD full RWEQ (double Q) combo total: (220 + 154 + 440 + 328 + 360)/100*125 = 1877

20 AD full RWEQ (triple Q) combo total: (220 + 154 + 154 + 22 + 16 + 16 + 18)/100*125 = 750

100 AD full RWEQ (triple Q) combo total: (220 + 154 + 154 + 110 + 82 + 82 + 90)/100*125 = 1115

200 AD full RWEQ (triple Q) combo total: (220 + 154 + 154 + 220 + 164 + 164 + 180)/100*125 = 1570

300 AD full RWEQ (triple Q) combo total: (220 + 154 + 154 + 330 + 246 + 246 + 270)/100*125 = 2025

400 AD full RWEQ (triple Q) combo total: (220 + 154 + 154 + 440 + 328 + 328 + 360)/100*125 = 2480

R level 3 combos:

20 AD full REQ (single Q) combo total: (220 + 22 + 18)/100*145 = 377

100 AD full REQ (single Q) combo total: (220 + 110 + 90)/100*145 = 609

200 AD full REQ (single Q) combo total: (220 + 220 + 180)/100*145 = 899

300 AD full REQ (single Q) combo total: (220 + 330 + 270)/100*145 = 1189

400 AD full REQ (single Q) combo total: (220 + 440 + 360)/100*145 = 1479

20 AD full RWEQ (double Q) combo total: (220 + 154 + 22 + 16 + 18)/100*145 = 623

100 AD full RWEQ (double Q) combo total: (220 + 154 + 110 + 82 + 90)/100*145 = 951

200 AD full RWEQ (double Q) combo total: (220 + 154 + 220 + 164 + 180)/100*145 = 1360

300 AD full RWEQ (double Q) combo total: (220 + 154 + 330 + 246 + 270)/100*145 = 1769

400 AD full RWEQ (double Q) combo total: (220 + 154 + 440 + 328 + 360)/100*145 = 2177

20 AD full RWEQ (triple Q) combo total: (220 + 154 + 154 + 22 + 16 + 16 + 18)/100*145 = 870

100 AD full RWEQ (triple Q) combo total: (220 + 154 + 154 + 110 + 82 + 82 + 90)/100*145 = 1293

200 AD full RWEQ (triple Q) combo total: (220 + 154 + 154 + 220 + 164 + 164 + 180)/100*145 = 1821

300 AD full RWEQ (triple Q) combo total: (220 + 154 + 154 + 330 + 246 + 246 + 270)/100*145 = 2349

400 AD full RWEQ (triple Q) combo total: (220 + 154 + 154 + 440 + 328 + 328 + 360)/100*145 = 2876

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Second buff iteration:

Zed Q base: 220

Zed Q base second hit: 220

Zed Q scaling: 90%

Zed Q scaling second hit: 90%

Zed E scaling: 80%

Zed R1 damage multiplier: 125%

Zed R3 damage multiplier: 155%

WEQ combo

20 AD full WEQ combo total: 220 + 220 + 18 + 18 + 16 = 492

100 AD full WEQ combo total: 220 + 220 + 90 + 90 + 80 = 700

200 AD full WEQ combo total: 220 + 220 + 180 + 180 + 160 = 960

300 AD full WEQ combo total: 220 + 220 + 270 + 270 + 240 = 1220

R level 1 combos:

20 AD full REQ (single Q) combo total: (220 + 18 + 16)/100*125 = 317

100 AD full REQ (single Q) combo total: (220 + 90 + 80)/100*125 = 487

200 AD full REQ (single Q) combo total: (220 + 180 + 160)/100*125 = 700

300 AD full REQ (single Q) combo total: (220 + 270 + 240)/100*125 = 912

400 AD full REQ (single Q) combo total: (220 + 360 + 320)/100*125 = 1125

20 AD full RWEQ (double Q) combo total: (220 + 220 + 18 + 18 + 16)/100*125 = 615

100 AD full RWEQ (double Q) combo total: (220 + 220 + 90 + 90 + 80)/100*125 = 875

200 AD full RWEQ (double Q) combo total: (220 + 220 + 180 + 180 + 160)/100*125 = 1200

300 AD full RWEQ (double Q) combo total: (220 + 220 + 270 + 270 + 240)/100*125 = 1525

400 AD full RWEQ (double Q) combo total: (220 + 220 + 360 + 360 + 320)/100*125 = 1850

20 AD full RWEQ (triple Q) combo total: (220 + 220 + 220 + 18 + 18 + 18 + 16)/100*125 = 912

100 AD full RWEQ (triple Q) combo total: (220 + 220 + 220 + 90 + 90 + 90 + 80)/100*125 = 1262

200 AD full RWEQ (triple Q) combo total: (220 + 220 + 220 + 180 + 180 + 180 + 160)/100*125 = 1700

300 AD full RWEQ (triple Q) combo total: (220 + 220 + 220 + 270 + 270 + 270 + 240)/100*125 = 2137

400 AD full RWEQ (triple Q) combo total: (220 + 220 + 220 + 360 + 360 + 360 + 320)/100*125 = 2575

R level 3 combos:

20 AD full REQ (single Q) combo total: (220 + 18 + 16)/100*155 = 393

100 AD full REQ (single Q) combo total: (220 + 90 + 80)/100*155 = 604

200 AD full REQ (single Q) combo total: (220 + 180 + 160)/100*155 = 868

300 AD full REQ (single Q) combo total: (220 + 270 + 240)/100*155 = 1131

400 AD full REQ (single Q) combo total: (220 + 360 + 320)/100*155 = 1395

20 AD full RWEQ (double Q) combo total: (220 + 220 + 18 + 18 + 16)/100*155 = 762

100 AD full RWEQ (double Q) combo total: (220 + 220 + 90 + 90 + 80)/100*155 = 1085

200 AD full RWEQ (double Q) combo total: (220 + 220 + 180 + 180 + 160)/100*155 = 1488

300 AD full RWEQ (double Q) combo total: (220 + 220 + 270 + 270 + 240)/100*155 = 1891

400 AD full RWEQ (double Q) combo total: (220 + 220 + 360 + 360 + 320)/100*155 = 2294

20 AD full RWEQ (triple Q) combo total: (220 + 220 + 220 + 18 + 18 + 18 + 16)/100*155 = 1131

100 AD full RWEQ (triple Q) combo total: (220 + 220 + 220 + 90 + 90 + 90 + 80)/100*155 = 1565

200 AD full RWEQ (triple Q) combo total: (220 + 220 + 220 + 180 + 180 + 180 + 160)/100*155 = 2108

300 AD full RWEQ (triple Q) combo total: (220 + 220 + 220 + 270 + 270 + 270 + 240)/100*155 = 2650

400 AD full RWEQ (triple Q) combo total: (220 + 220 + 220 + 360 + 360 + 360 + 320)/100*155 = 3193

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Conclusion: The new iteration outshines the old one in most situations.

A simple WEQ combo will do more damage until the 300AD breakpoint, where the old buff will outscale.

Early mid game hitting 1Q under deathmark makes the old iteration win. Late game the damage is almost the same, shifting towards the new iterations the more you autoattack under deathmark while to the old one if you hit more E's.

Hitting more than 1Q under deathmark will make the new iteration win at any stage of the game.

Edit: formatting