Rapamycin

☠ High Risk

[removed]

Posted Jan 12, 2019, 7:13 PM UTC

016
dreamertreader•

High risk tag please

6
VorpeHd•

Why?

1†
tnegaeR•

It’s a powerful immunosuppressant used to combat organ rejection?

3
verslaluneOP•

It's all about dosing. It's a powerful immunosuppressant at high daily doses, but it's clinically beneficial for a lot of diseases at low doses with minimal side effects.

3
tnegaeR•

I would be very hesitant to call it a nootropic

2
VorpeHd•

Thanks ,but I'm not pharmacist so maybe that's why I asked? Let's downvote OP too since he asked a question.

1
tnegaeR•

You’re on the internet, I guess I assume you’re able to use google to identify things you’re unfamiliar with.

0
argumentetsoul•

There is a lot of American/Asian suppliers, but i have not found a European one.

1
verslaluneOP•

Would you be able to provide the names of those suppliers? You can PM if you'd like.

1
[deleted]•

[deleted]

0
agentsprovocateur•

What are the nootropic benefits?

1
verslaluneOP•

Admittedly, none. It's an mTOR inhibitor. I have a genetic defect in the PI3K/AKT pathway which is part of the TOR complex. Inhibiting mTOR is clinically proven to give benefits for diseases with my genetic defect. Rapamycin essentially mimicks fasting, since it also indirectly inhibits IGF-1 and starts the cellular process of autophagy.

Just thought someone here knows a supplier for me. The use of sirolimus in this case is 'off-label', but the drug is very well tolerated with minimal symptoms at weekly doses of 5mg.

2
agentsprovocateur•

I see

1
[deleted]•

[removed]

1
verslaluneOP•

Thanks! I'll check them out.

1