The active drug was a solution of racemic ketamine 50 mg/1 mL. Evidence for determining optimal dosing and regimen are scarce and oral administration of ketamine has a low, unstable, bioavailability, which might be affected by food intake and personal metabolic profile.9 We chose to extrapolate the dosage from those described for intravenous administration (0.5 mg/kg) and tailor it based on expected oral absorption (17–23%)9 and specific participants’ body weight. This is in accordance with previously reported dose regimes of oral ketamine for depression.11,13 Therefore, we decided to administer 1 mg/kg. Regarding the dosing schedule, because twice and thrice weekly administration has been suggested to have similar results,5 we chose to give it thrice weekly considering the lower dose given, and the unstable oral bioavailability.
So, did they squirt a syringe of fluid in their mouths? I think that's what they are saying.
If it was .5 mg/kg that would be a pretty low dose, and I have always heard that oral (swallowed) had even lower absorption than 17-23%. Still, it's interesting and looks like a well formed study.
I wonder if just upping the dosage would be a way to get around all this absorption stuff. A pill is pretty convenient.
Yeah they mostly do it for adherence and to have finer control of dosing since insufflation is pretty unreliable due all kinds of factors with nose anatomy, mucous membrane, etc., I've always played with these studies with internasal microdosing.
I wonder if just upping the dosage would be a way to get around all this absorption stuff. A pill is pretty convenient.
That's the solution my doctor has used with lozenges. I was talking to a local psychiatrist and he's terrified of this idea. He fears increased side effects. But most of the side effects become much milder with continued administration. You can see a reference to that in this study and it has been my personal experience as well.
So, did they squirt a syringe of fluid in their mouths? I think that's what they are saying.
If it was .5 mg/kg that would be a pretty low dose, and I have always heard that oral (swallowed) had even lower absorption than 17-23%. Still, it's interesting and looks like a well formed study.
I wonder if just upping the dosage would be a way to get around all this absorption stuff. A pill is pretty convenient.
Yeah they mostly do it for adherence and to have finer control of dosing since insufflation is pretty unreliable due all kinds of factors with nose anatomy, mucous membrane, etc., I've always played with these studies with internasal microdosing.
That's the solution my doctor has used with lozenges. I was talking to a local psychiatrist and he's terrified of this idea. He fears increased side effects. But most of the side effects become much milder with continued administration. You can see a reference to that in this study and it has been my personal experience as well.
So you take it orally? pills?
Lozenges, under the tongue.
Oh I meant possible upping the convenience even more by taking a pill, and simply upping the dose to accommodate for poor absorbtion.
The lozenges can be annoying, trying not to swallow, etc and absorption varies anyways.