How does cycling HRT affect your transition?

As someone who's intermittently self-medded over a period of about 2 years (think 3 months on, then 8 months off kind of thing, as well as periods when I had to ration my hormones by taking them once every two days only), is there any truth to the idea that HRT becomes less effective if you cycle it too much? How does an irregular HRT schedule affect your transition in the long run? I am on a medically prescribed regimen of HRT now, but I'm a bit worried if my prior cycling had any negative effects on my endocrine system.

Thanks