Yeah fullscreen sorry i should have said. I also turned off steam overlay just in case that was causing an issue. During normal gameplay it rarely happens but once i hit a boss it happens throughout the full fight thats why i think it may be something to do with the settings but im not having any luck!

mouse smoothing is disabled by default. Is the game set to exclusive fullscreen? This may help

My mouse keeps locking up not letting me aim or shoot. Is anyone else having this issue or know what might be causing it? Locks up for 2-5 seconds every so often usually during boss fights which is rather annoying. 

This is the only game it happens in and has never happened before so i dont believe my mouse is dying/broken. Vsync turned off also tried to turn mouse smoothing off but the console wont change to 0. 

Any ideas?

Mouse locking up