Computer is receiving multiple rapid inputs from somewhere

Hello, I'm hoping someone here can help me narrow this down- I'm losing my mind here.

My computer has recently (over the last month or so) started negating my mouse clicks and is receiving multiple rapid succession inputs that negate any of my mouse clicks. Examples: Spotify app when opened will quickly cycle through about 10 songs, land on a random one, and keep playing that one, if I click on another song nothing happens. If I close the app and reopen it, the same thing happens-- rapidly cycling to a random song, and no inputs are accepted. At first I thought it was an issue with the Spotify app so I uninstalled, reinstalled, clean installed, etc.

The next case was in Blender. I was following some tutorials and noticed I couldn't select any vertices unless I dragged to select multiple. Thought it was an issue with Blender, uninstalled, reinstalled, clean installed, etc. No fix.

Now Windows won't let me select any open program by mousing over the task bar and clicking an open window. The only way I can successfully switch windows is by alt-tabbing through the list and either landing on one with alt-tab or by then clicking the window while in Task View.

I thought this was an issue with my keyboard so I bought a new one as I didn't have any others to test with. Nope, issue persists. So I tried an old mouse, same issue. I've noticed it seems to go away when I first install software for my keyboard (Logitech) but then comes back randomly or after a restart. I've run Windows updates, updated the firmware on my mouse and keyboard, run optional updates for every program that has one queued up. I've tried disabling programs, starting in safe mode, removing old programs, I've swapped out my mouse/keyboard... I'm at my wits end. This is effecting my productivity and my sanity, please, if anyone has any suggestions I'm open to anything

I'm running Windows 10 64-bit on version 19042.804 (20H2)

EDIT: Virus scan and Malware scans were run, both came back clean. I've now reinstalled Windows which fixed the issue temporarily but it's now back in full force.

EDIT 2: May have found the solution? I swapped the USB ports my keyboard was plugged into and also removed a cheap USB 3.5mm audio adapter I got off Amazon, key/mouse function seems to have returned to normal for the time being... But then again it's been functional before so I'll give it time and determine whether it's actually fixed or not