Remicade reaction on 3rd dose 🥴 Have some questions…

Had 2 loading doses of Remicade and was totally fine during and after both. They started working and my UC symptoms greatly improved.

Today I had my 3rd infusion and the last of the loading doses. 15 mins in I started having an reaction. Face flushed red and felt pressure building up. My breathing became shallow and difficult.

Does this mean antibodies are already building up? And will this mean that the countdown to Remicade failing has already begun?

Has anyone had a reaction like this early in the loading phase but went on to have a long history with good results from Remicade?