Source
PartyOperatorOP•

Discussion:

A single dose of the adenovector vaccine ChAdOx1 nCoV-19 following natural infection elicited a robust serological response with broad neutralizing capacity against SARS-CoV-2 wild type and variants of concern. Neutralizing antibody levels exceeded those after two doses of the mRNA vaccine BNT162b2. Our data support that a single dose of adenovector vaccine serves as an efficacious immune booster after priming with natural SARS-CoV-2 infection up to at least 11 months post infection.

In other words: if you've previously had COVID-19, a single dose of AZ vaccine generates antibody levels at least as high as two doses of Pfizer/BNT would against the original, UK, South African and Brazilian variants. Given other results, it seems pretty likely a single dose of Pfizer, Moderna or any other effective vaccine would likewise generate very high antibody levels in people who've recovered from COVID-19.

The current policy of encouraging people who've had COVID-19 to get two doses is largely about practicality and simplicity rather than science (not everyone who thinks they've had it really did, not everyone who had it tested positive, it's easier to tell everyone to get two doses etc). But if doses were limited and the complexity could be handled, we could skip a pretty significant number of second doses.

12
lokfuhrer_•

This is really good news. The only downside is if it becomes a requirement to have both doses to travel, by which point it probably becomes more messy than it’s worth to differentiate and we’ll just carry on plodding on as we are now.

Good news though.

2
CarpeCyprinidae•

For what it's worth, France has already decreed that people who've recovered from Covid are considered fully vaccinated after one dose of any vaccine

6
lokfuhrer_•

Hopefully it becomes at last a European standard!

2
manwithanopinion•

The antibodies of someone who recovered from covid last a about 7-8 months not a lifetime. I have no idea what will happen to France in the summer and how the French open will take place.

-5
[deleted]•

Antibodies for everything fade if you have recovered from it, vaccine antibodies will fade too. The important part if your body retains memory to make those antibodies again in the future.

9
CarpeCyprinidae•

The antibodies of someone who recovered from covid last a about 7-8 months not a lifetime

Unproven

And also possibly irrelevant given that the body can usually regenerate antibodies if needed after their prevalence drops away. And given that T-cell immunity is the real long term protection.

France is facing a disaster anyway due to a recalcitrant population and a devastatingly inept government, but their recognition of natural immunity isn't the greater part of the problem, or necessarily a problem at all.

7
TheNiceWasher•

The current policy of encouraging people who've had COVID-19 to get two doses is largely about practicality and simplicity rather than science

to be fair, this paper was published pre-printed yesterday...

2
PartyOperatorOP•

Sure, but there's been evidence from other vaccine studies. This is the first I've seen that covers the main variants of concern and the AZ vaccine and it basically confirms that vaccination after infection does what we thought it would.

1
korokunderarock•

Had we not experienced the immense supply bottleneck in testing in the earliest phase of the pandemic (thinking of the end of March 2020 when we got stuck on 5-10k tests a day), I wonder if this would have been more feasible. As it stands there must be a huge, huge number of people who will simply never know if they had it.

1
Kingrockerone•

How much antibodies does one have after a covid infection and how does it compare to two jabs of the vax?

1