Hows the size of the phone? Able to use it 1 handed?

Your thumb will get some stretching. You will adapt to it though and begin the appreciate the larger viewing area.

I have large hands and I have to loosen my grip and slide the phone to hit the upper-left corner of the screen (while holding right-handed). A lot of back buttons happen to be in the upper-left, so this happens more than I would have thought.

With not large hands, I'd say plan on using your other hand to fully operate the phone.

I have fairly large hands and have to let go of the far side to hit the google search button on the opposite corner one handed. That combined with the slippery back is a bit annoying. That said, I tried to get some files off my og droid and navigating the 3.7" made me feel like a proctologist. IMO a huge screen is better than easy one handed operation.

I think I have average size hands (or slightly larger) for a White American Male and I have sometimes have trouble using the left side of the screen. Also note I'm not using a case. I do believe that because the phone is so slippery I cant get a secure enough grip in one hand to reach my thumb across the screen, perhaps the right case will add the grip and shape needed to more proficiently use it one handed.

Coming from an iPhone 3GS, it was a clumbsy experience at first, but after a couple days, I have it down. It was hard at first to drop the notification screen, or hit the app market button on the applications screen, things like that. I think I just got used to it.

I have medium sized hands. It's kinda big, but I can use it one handed. I just have to put my pinky at the bottom to keep it from sliding out of my grip. Still, it's nice to have a big screen.

It's perfect. Medium hands.

I am a medium-sized man with medium-size hands and have had the gnex for all of 2 days.

I'm coming from a Droid X. While the phone is noticeably larger than a DX, I don't find it much different to handle. One-handed operation is fine for me though, like on my DX, if I want to typed quickly I need to use two hands.

Two hands for some tasks, one for others. I'm sceptical of any claiming to be able to do everything with one hand...unless they have very large hands.

The nice thing though is the screen is wide enough to type with both thumbs in portrait.

yes, it is large, but with a med to large hand you will get used to using it with one hand. I am timid with it so got the otterbox defender case the week after bought it b.c i was just afraid, but never came close to dropping it. i say play with it in store or find some one who has one (a sales man in the store will certainly have one in his pocket so you wont have to deal with the tether on the phone) and check it out. the way i see it; you don't buy clothes or a car with out trying them on or test driving first...

Here's a decent review of the size compared to hand size:

http://www.pcmag.com/article2/0,2817,2397742,00.asp

I have a smaller thumb but I manage just fine. I wouldn't want a bigger phone though.

I have fairly large hands and I find one-handed operation to be extremely difficult in a number of situations.

It's a big trade off for such a gorgeous screen.

It's big but if you have average hands you can stretch across the screen if you need to. Not a huge problem for me really

I have kind of small hands. I hold my phone with my left hand, and have a bit of trouble stretching to the top right, but it's not awful by any means.

Its just a tad on the large size for me when out and about... obviously when your at home/sitting down its fine

I have large hands, so I find it perfect. I hold with my right hand, and I have no problem hitting the opposite corner without any grip oddities. I'd go so far as to call it the most ergonomic phone I've used to date (I'm coming from the iPhone world). This is obviously a very personal thing, though...