Source
r/sarmssourcetalk•
LegLevelGround

Why does dosage vary to such a large degree? Why is stacking such a bogeymen?

Now, I know what your thinking “how does talking about this this help anything. Just take your dosage and don’t go overboard.” Let me explain.

As we all (hopefully) know, SARMs exhibit their effects by binding to skeletal AR and promoting anabolic effects. In addition, dosage can be large/small due to how the drug is metabolized (how much of it makes it to the actual receptor), the half-life of the compound, and how selective it is. In addition, people gain AR as they both use AAS/SARMs and increase muscle mass.

My question is, in addition to the aforementioned reasons, why does dosage of selective molecules differ to such an extent. Why can I take 30mg of MK-2866 and feel no extreme side effects while 30mg of LGD-4033 will create a shit ton of androgenic activity and spillover?

Secondly, if we have a ceiling to how much actual SARM/AAS our ARs can bind to and use, why is stacking SARMs so frowned upon. I don’t dispute I was one of these people who hated stacking. However, can two (or more) SARMs be bound to the AR fully without “overflow/spillover” (and side effects)? Yes I understand binding affinity plays a role, but if there are “enough ARs to go around” ,wouldn’t everything be fine in regards to “overflow/spillover?”

By overflow or spillover I mean unbound androgens (because all skeletal ARs have been saturated) bind to AR (among other receptors) outside of skeletal muscle and wrecking havoc.

These are just my thoughts and shower thoughts when it comes to SARMs. If I have any information that is incorrect, please let me know (as well as link an article, study, or video if possible so I can learn). I’d rather be wrong then ignore new learning material.

Posted Jul 15, 2021, 11:54 PM UTC

116
kingshit108•

Tbh though how do you know you fully saturated your androgen receptors...

You don't..

I can tell you with a straight face that 30mg of a sarm.. that has no ester and has a half life of probably 8 hrs isn't fully saturating shit

5
LegLevelGroundOP•

This is not to attack but just wondering. Why does Ingesting beyond a certain limit (for SARMs) yeild result that have diminishing returns. If they are never fully saturated, wouldn’t there be a positive 1 relationship between gains and dosage. Like there is a ceiling. This could possibly be because LGD isn’t perfectly selective and will bind to AR (and other shit) across the body; at high doses this binding could cause side effects. What do you think?

1
kingshit108•

I think its less about androgen receptors and more about the bodies ability to synthesize muscle..the body can't shuttle and lay that much material, that's why long low dose cycles out perform short heavy cycles...

I'm not stating anything as fact here, only doubting the ability of a few mg of powder completely saturating androgen receptors across the entire adult body

3
PolHolmes•

It's complete bro science, then it's circle jerked around this sub like it's gospel. No evidence whatsoever that stacking is bad

3
betapen•

Receptors up regulate, but you might have some competition for receptors and that's where stacking might not be ideal.

But will still be effective. Imo stacking too much is a bad idea as it complicates things when you get sides Figuring out what is causing what can be tricky and resolving it might not be so strait forward. Unless someone has a coach or is experienced I normally recommend not to stack more than 2 compounds. Like pros run grams of shit and still grow... so saturation is kinda bro science imo.

2
innovatedname•

Not an expert. But consider an analogy with alcohol, is it really so surprising that 1 bottle of vodka has a shit ton more effect than 1 bottle of beer? And that people advise against mixing drinks?

1
ProteinCrackhead•
  1. LGD is much more powerful than ostarine mg per mg just like how superdrol is stronger compared to anavar...
  2. Because you are crashing your testosterone levels and estrogen to the ground without replacing it
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LegLevelGroundOP•

What is your number 2 responding to. Even with a test base, androgenic sides occur

0
ProteinCrackhead•

You said secondly why is stacking sarms frowned upon. Because you are crushing your test/est without replacing them. If you take test then your test and est are covered and you are not going to feel like shit. And it would help retain the gains as well.

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LegLevelGroundOP•

Ofc a test base is a given. I’m just saying I don’t understand why stacking is a bit demonized, esp if you have experience. Also tour answer goes for any Sarm cycle.

0
ProteinCrackhead•

If you use 1 sarm you are likely just going to be suppressed, stacking 2 will have you very heavily suppressed or shutdown

2
calvesofsteel1•

20mg a day of lgd gives me a lot of side effects while 100mg a day of S4 is tolerable. I think some are more attracted to androgen receptors in muscle and less attracted to things that bind and neutralize them so their effect is greater at a low dose like LGD4033.

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