Help with installing Nest to a wireless Honeywell module THM5320R with heat pump

Hello, I installed a 2nd Gen Nest on our main floor a year or so ago with no issues. I recently purchased another 2nd Gen Nest learning thermostat for our 2nd floor zone. Upon removing the old Honeywell thermostat, i realized it was a wireless unit and connected to a Honeywell module in the basement (THM5320R).

This Honeywell module is also connected to a heat pump. Now i'm lost on how to install this and if its even possible?

Here is a picture of the current wiring on the THM5320R

If it is possible to use, do i need to install the Nest next to this and then put a wireless temperature sensor upstairs?

Any help would be greatly appreciated!