Any issues with injecting small bubbles with HCG?

I am only able to get HCG in 10000 IU vials right now. So I preloaded a bunch of syringes to freeze. in order to allow for expansion, I took in a small amount of air in each syringe. After I unfreeze them, I've been purging the air out of the syringe, but I can't seem to do it without losing a bit of HCG. Would there be any issues with just injecting the small air bubble subcutaneously? I know it's not fatal but just curious what, if anything, would be the negative.

Posted May 8, 2022, 4:02 PM UTC

28
InfiniteLlamaSoup•

No issue, air will just get broken down.

4
Chaotic_Boots •

Can you freeze HCG? I thought it would break down if you froze it.

2
Testingtesting57OP •

I've read of several people doing it, so assumed it would be okay. But if someone has better information, I'd be happy to hear it.

1
muffinscrub •

It should be fine, HCG is manufactured by subjecting it to very low freezing temperatures then drying it in a vacuum at around 30° Celsius. As long as it only goes through 1 freeze, thaw cycle.

I would personally be way hesitant to not freeze HCG in syringes due to the plastic and rubber syringes are made out of and sterility issues that could arise.

Put the air against the plunger and inject. A small amount of air isn't going to do you any harm.

2
Testingtesting57OP •

I would not keep it in syringes, other than it being the easiest way to transfer the reconstituted HCG into something I can freeze in smaller amounts. But you're saying that the freezing would mitigate sterility issues with the plastic and rubber?

1
muffinscrub •

Once you remove the reconstituted HCG from the original vial, it's hard to guarantee it's still sterile. It probably is ok though but still a risk.

I am just unsure of how much plastic degradation you would experience. It's not recommended to store medications in single use syringes.

1
PatriotUncleSam •

Plastic “sheds” when exposed to heat and cold.

1
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