Co-administration of neuro-steriods with benzos may prevent tolerance. Thoughts?

See section 4.4.3 of https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321276/

Moreover, co-administration of the neurosteroids allopregnanolone or pregnenolone (but not dehydroepiandrosterone) prevented the development of tolerance after chronic treatment with either triazolam and diazepam [154].

Posted Sep 21, 2022, 12:46 AM UTC

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texmexdaysex•

Would be great if it could be used for rapid cessation without serious withdrawal symptoms.

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GrenadeAnaconda•

That makes sense. Allopregnanolone is critical for the function of GABA signaling especially as it relates to mood. I wonder if low dose fluoxetine could do the same?

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scatfiend•

yeah, I was thinking this

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