Remote work and Bioinformatics

Hi all,

I checked the FAQs for my situation but most of the pinned threads were pre-pandemic and thus pre remote-work boom. I am currently pursuing an MS in bioinfo. Having finished what I believe will be the toughest course for me, I'm trying to think about my future. Before, the nature of my work meant I had to live in Boston / SF / San Diego to get a good job, or at least, to have a proper amount of companies such that I could job hop every two years and work my way up to scientist, or some ultimate position where I was still in the laboratory. Now is seems that the nature of my new work, this will not be the case. So I'd like to hear from the community on the following questions or points of discussion:

1. What percentage of computational biologist / bioinformatics scientist positions do you believe are remote? Is it industry standard expectation to want the bioinformatician to move to the same city as their employer?
2. If indeed my position will be remote, as I am hoping it will be, do you think I would be limiting my career by moving to a non-hub? (US). Like a city which has decent size but definitely not a lot of biotech or pharma companies? (This is most or at least many major US cities).
3. Do you think I'd be in a better position by moving to Boston / SF / San Diego (really really really hoping to not have to do this). I love SD but its like 3k miles away from my family.