I'm a relative newbie, having mostly done PALS and Arkiv System pouches, plus some totes, tool rolls, toolbags, drawstring knapsacks, wallets, and a smattering of mods and mends. But I've done all my sewing by hand, and haven't seen many notes here on r/myog or elsewhere about that. Perhaps by sharing, I can help others catch up, pass me, and share further tips of their own.
For context, most of my work so far has been in high-denier nylon and heavy cotton canvas. My go-to is 1000D Cordura. I've primarily sewn heavier weight threads, like Tex 100 Mara, Tex 135 Anefil, and more recently Tex 200 Mara for very stout seams.
For needles, I've found it's possible to thread three-ply Tex