It seems that the restrictions on interstellar travel are the real issue and danger to humanity. Nothing can happen without the Guild. And the Guild only allows travel that it approves of. And the Guild only approves of travel that will not affect its monopoly on travel.
Because of the ban on 'thinking machines', FTL travel can only be accomplished by a Navigator, thus the monopoly on travel by the Guild. But, was it really not possible to have computers that were 'advanced enough' to make travel safe without the risk of those computers becoming sentient? I mean, after the death of Leto II, how else does humanity begin their great migration to the stars? Surely that didn't depend on t