r/dnafragmentation

779 archived posts · Sep 2018 – Aug 2026

DNA Fragmentation of Sperm Information and Resources

r/dnafragmentation

You can easily share info here and on the website at www.dnafrag.com || Male Factor Infertility and sperm issues, Sperm DNA Fragmentation and how it affects fertility miscarriages, recurrent pregnancy loss (RPL), IVF issues with poor blast formation, embryo development, unexplained diagnosis of infertility, importance of testing for DNA fragmentation after you have a miscarriage or infertility work up and how a sperm analysis is a poor predictor for male factor infertility or fertility issues.

Created Sep 8, 2018 · restricted

2.1KMembers (last snapshot)

779Archived posts

www.dnafrag.com "Sperm DNA damage is the major cause of defective sperm function. DNA damage includes DNA denaturation and sperm DNA fragmentation (SDF) and maybe the common underlying aetiology of infertility, recurrent spontaneous abortion (RSA) pre- and post-implantation losses, accelerated aging, and childhood cancer (1). Oxidative DNA damage is an important factor, which affects sperm quality and increases risk of genetic and epigenetic abnormalities. Accumulation of oxidized DNA adducts like 8 hydroxy2deoxyguanosine (8OHdG) can impair function of denovo methylases and result in genome wide hypomethylation which compromise genetic stability (2). Thus, loss of sperm DNA integrity not only impacts reproductive and psychological health of the infertile couple but also increases childhood disease burden. Maintenance of integrity of germ cells is therefore crucial for fertility and success in assisted reproductive technologies and for the health and well being of the next generation". https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643659/

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