Vampire Story with Trans Themes Advice

Hello! I'm totally new to any kind of writing so forgive me if I'm naive. I've had an idea for a while to write a vampire x werewolf turning story/romance with Trans themes. I know the trope has been used to hells and back but I wanted to do a more character driven story that is a little less focused on large scale lore and world building and more characters learning about themselves and each other. Do y'all think that could be a compelling story and, if so, any tropes that I should avoid? Any help is greatly appreciated!