r/SSRIs•
hp774465

Can a new SSRI cause a sudden, intense depression?

Luvox

Curious if anyone else has been through this, it was the first time I’ve ever experienced anything like it. I’ve been on and off SSRIs for 20 years. Recently my doc helped wean me off Effexor, and I switched to Prozac but it was causing teeth grinding at night. She switched me to Luvox after a week off Prozac (she said because of long half life). Within days of starting the Luvox I had an intense bout of depression like I’ve never had in my life. I reached out to my doctor after about a week of this because it was getting scary and asked to be taken off of the Luvox. She said she wasn’t sure that it would have caused depression so quickly, but agreed to switch me to Clomipramine. Within a day or two of the switch my depression was completely lifted and I’ve felt great ever since. I guess I’m curious if it’s even possible that the Luvox would have caused such a sudden negative change (and that the Clomipramine would have worked so quickly). I was under the impression these medicines could take weeks but I can’t explain the intense depression I went through and how it’s now over (I don’t have a history of this, more just anxiety). Any insight would be appreciated!

Posted Mar 16, 2026, 11:54 PM UTC

12

Comments aren't archived yet

This post had 2 comments on Reddit. Comments for this period haven't been loaded into the archive yet.