Optimal Nogardnit Usage

I've noticed that, if I pause to use a clickable too soon after going (back?) into active mode, the reward is next to nothing; on the other hand, the countdown timer for the next clickable doesn't start until I use the one I have, so not using it means waiting longer for the next one. (Yes, I know it's probability, not a timer, but the probability is 0.00% so long as there's already one there). Has anyone found a "sweet spot" for how long to leave a clickable unused? Does such a sweet spot even exist?