r/Stims•
PleasePasta

toxicity of low dose methamphetamine (Desoxyn)? What about other stimulants?

I apologize for writing this, without really taking or having the time to search more on my own first.

I'm still trying to learn about stimulants and the pharmacology, although I am still just as ignorant as I was from my last post.

 

However, I have heard multiple times that the studies on Methamphetamine are generally "for those using high dosages chronically", but that the information available on lower dosages is "less studied"?

Still, that is just word of mouth so to speak, and I was just trying to further understand the risks of low dosage Methamphetamine compared to say Amphetamine, Methylphenidate, or other stimulants... outside of the addiction/abuse potential

 

Any other thoughts would be welcome as well :)

Posted Mar 20, 2017, 5:36 AM UTC

111
Ritalin_Magnet•

IIRC most studies on low dose D-methamphetamine (5-10mg) saw only benefits.

2
PleasePastaOP•

So when does "low dose" end?

1
Chaco_Jesus•

10mg

1
PleasePastaOP•

What is the toxicity level and risk for up to say 40-50mg, such as Desoxyn is prescribed up to at times?

1
Chaco_Jesus•

Increased risk for addiction at those doses. Toxicity is probably low considering some users use way more than 50mg and come out fine if they get clean

2
24kgoldring•

Toxicity is incredibly overrated, I've never found many studies showing much beyond dopamine receptor damage with chronic addicts, which also heals its self over time.

2
TakeMeOver224F-MethPHd•

Low dose amphetamine and methamphetamine are pretty much the same regarding toxicity (there was a study that I CBA to look for right now).

It's the higher doses and higher addiction potential (mostly because of smoking/IV) of high dose meth that's the issue.

Same general rules apply: keep doses low, don't use every day, EAT DRINK SLEEP.

2
24kgoldring•

Low dose meth shows neuroprotective capability strictly, if I remember the studies correctly.

1