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r/AskDrugNerds•
PleasePasta

Methamphetamine questions

Hello!

 

I was wondering if Methamphetamine has information for low oral dosage toxicity or risk factors. I realize that Desoxyn is prescribed in the United States (from 5mg starting dose, up to ~50mg?).

I was just trying to locate some sources for the quotes I have heard many times, such as "the studies for Meth showing the toxicity, only really cover excessive, high dosages". I was able to get these links from r/stims so far:

However, I wondered if there was more studies, or relevant information/knowledge.

 

In addition, I was wondering if Calcium Carbonate, as well as gastrointestinal disorders (Crohn's, IBS/IBD, Colitis, etc) would in most cases affect the absorption, strength, or duration of the chemical.

I saw that Calcium Carbonate was listed as interacting with Desoxyn in "Moderate" levels on a different website, but didn't fully understand why.

Posted Mar 21, 2017, 5:09 AM UTC

210
FW900•

I have wrote at length on this and have posted many, I'd estimate dozens, of METH studies that used an HED < 0.5mg/kg. Not once in any of these studies in such doses did the drug show any neurotoxic effect (at least in fully developed animals). The only thing close that showed deleterious effects on the brain was a study that used an HED of 30mg in rats(?), however it was IV which has substantially different (much more sudden) pharmacokinetics vs oral administration.

The below is from an older post of mine:

The "directly neurotoxic" is a false claim that was originally stated in the cited Molecular Neuropharmacology textbook which only cites a study on abuse. The second citation does not make the claim. The third citation stems from a paper on methamphetamine abuse and looks at abusers' brain abnormalities. Methamphetamine is neurotoxic in recreational doses that are nowhere near the range of 5-20mg oral therapeutic dose.

There remains ZERO evidence that methamphetamine is neurotoxic in therapeutic doses. In fact, imaging studies that look at the effects of methamphetamine at the synaptic level in low doses have found the opposite: that low-dose methamphetamine is neuroprotective in very low doses!

http://www.sciencedirect.com/science/article/pii/S0028390811001900 https://www.ncbi.nlm.nih.gov/pubmed/25724762 >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939399/

2
MuhammadTheProfit•

Take what I have to say with a grain of salt because I have no idea what I'm talking about, but my assumption is that methamphetamine will be potentiated by calcium carbonate. I know people take calcium carbonate to potentiate their amphetamine so I'm guessing methamphetamine reacts similarly. I believe it has to do with lowering stomach acid but I could be wrong.

On its toxicity, I read a study a couple weeks back about it being neuroprotective in small doses. I'm not sure if that's true for constant regular use though, I'd have to glance back on the study but I'm sure you could Google it

1
LordDongler•

Correct, lowering the acidity of the digestive tract increases bioavailability by making it easier for your body to absorb it

1
LordDongler•

There is no neurotoxicity (actually has neuroprotective effects) in low doses (probably around 15-20mg (.5mg/kg)) and has minimal toxicity until around double that (1mg/kg)

1
eleitl•

I realize that Desoxyn is prescribed in the United States

It isn't prescribable where I sit. The duration of action is also too long, so it is more liable to disrupt sleep.

0
PleasePastaOP•

I slept last night about 5-6 hours after taking Meth :D

2
eleitl•

When did you take it? How many mg? Are you a habituated user?

5-6 h is way too low. I need 8 h, or I cannot function that well. I have no issues with 30 mg Lysdexamfetamine taken in the morning. In fact, I sleep better.

1
PleasePastaOP•

30-50mg, oral?

I was using speed pills and stuff which I thought were Meth, but I've come to the conclusion must be something else.

However, I have done a lot of crystal shards orally and nasally over the last few weeks, and sleep totally fine. Eat totally fine. Pupils shrink. On and on.

 

I can sleep after Adderall or any other stimulant, in fact I get a bit sleepy or relaxed almost. But, yet I also get focused, better bodily control, more sociable, more sexual, and mainly... more happy and less depressed.

1
eleitl•

It sounds like you might have ADHD.

I've been through atomoxetine, methylphenidate sustained release and now lysdexamfetamine, and the latter works best so far. Calms me down, gives more focus. Less din in the head.

1