Since you've already been back to work for a day, you can start a new one.

Do you know what I should do if I went on leave for symptoms, they went away, and then at then after my leave I have symptoms again? Not sure If I should go in then go on another or just take another

Start a new one. It's a new issue, not related to the previous one.

Long story short, I came back today from a paid LOA. However, halfway through the day my room mate was sent home and their doctor mandated quarantine for the entire household. They were paid for my quarantine, but would Sedgwick really approve a new LOA after just one day or would they try to roll the two together since my previous claim hasn't been closed out yet due to the weekend?

Back to back LOA question